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Cancer Investigation Volume 30, 2012 - Issue 2
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CELLULAR AND MOLECULAR BIOLOGY

Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

Jörg EllingerKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,Correspondence[email protected]
,
Philip KahlInstitut für Pathologie der Universität zu Köln, Cologne, Germany,
,
Johannes von der GathenKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,
,
Lukas C. HeukampInstitut für Pathologie der Universität zu Köln, Cologne, Germany,
,
Ines GütgemannInstitut für Pathologie, Universitätsklinikum Bonn, Bonn, Germany,
,
Bernhard WalterUrologische Universitätsklinik, Universitätsklinikum Erlangen, Erlangen, Germany,
,
Ferdinand HofstädterInstitut für Pathologie, Universitätsklinik Regensburg, Regensburg, Germany,
,
Patrick J. BastianUrologische Klinik und Poliklinik, Universitätsklinikum Großhadern, Munich, Germany
,
Alexander von RueckerInstitut für Pathologie, Universitätsklinikum Bonn, Bonn, Germany,
,
Stefan C. MüllerKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,
&
Sebastian RogenhoferKlinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Bonn, Germany,
 show all
Pages 92-97 | Published online: 02 Feb 2012
 
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Abstract

Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.

ACKNOWLEDGMENT

We thank Doris Schmidt for technical assistance.

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