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Cancer Investigation Volume 30, 2012 - Issue 2
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CLINICAL TRANSLATIONAL THERAPEUTICS

Quality of Life and Toxicity of Stereotactic Radiotherapy in Pancreatic Tumors: A Case Series

Gabriella MacchiaRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, ItalyCorrespondence[email protected]
,
Alessio G. MorgantiRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Savino CillaRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Edy IppolitoRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Mariangela MassaccesiRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Vincenzo PicardiRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Gian Carlo MattiucciRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Pierluigi BonomoRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Rosa TambaroRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
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Fabio PacelliRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
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Angelo PiermatteiRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Marco De SpiritoRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
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Vincenzo ValentiniRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
,
Numa CelliniRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
&
Francesco DeodatoRadiotherapy Unit, Palliative Care Unit, Medical Physics Unit, Surgery Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II”, Università-Cattolica, Campobasso, Italy, Radiotherapy Department, Università Cattolica, Rome, Italy
 show all
Pages 149-155 | Published online: 02 Feb 2012
 
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Abstract

Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients’ quality of life.

ACKNOWLEDGMENT

We thank Perla Avegno and Milly Bwenge for reviewing the manuscript.

DECLARATION OF INTERESTS

The authors report no declarations of interest.

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