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Cancer Investigation Volume 30, 2012 - Issue 3
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CAUSATION AND PREVENTION

ERCC1 Polymorphisms and Risk of Adult Glioma in a Chinese Population: A Hospital-Based Case-Control Study

Nu ZhangDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Lu-Yang LinDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Lie-Lie ZhuDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Fan WuDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Hao WenDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Da PanDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
,
Yu-Chuan HuangDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,China
&
Da-Qing ChenDepartments of Neurosurgery, and Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang Province, China, West China Hospital, Sichuan University,ChinaCorrespondence[email protected]
 show all
Pages 199-202 | Published online: 04 Sep 2012
 
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Abstract

To examine the associations of two polymorphisms in excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1) gene, C8092A (rs3212986) and T19007C (rs11615), with the risk of adult glioma, we performed a hospital-based case-control study with 257 new cases of glioma and 278 controls in Wenzhou, China. Results showed that polymorphisms C8092A and T19007C in ERCC1 gene were not associated with the risk of glioma in a Chinese population. Further studies in Chinese populations with larger sample sizes are still warranted.

ACKNOWLEDGMENT

We thank colleagues at the Second Affiliated Hospital of Wenzhou Medical College for their help and support in the fieldwork of this study.

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