Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro

Abstract

Small cell lung cancer (SCLC) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. Caveolin-1 plays an important role in the development of a variety of human cancers. This study sought to investigate the influence of Caveolin-1 on the apoptosis of SCLC in vitro. We demonstrate that higher expression of Caveolin-1 leads to inhibition of cisplatin and Ultraviolet Radiation (UVR)-induced apoptosis in SCLC cells; and also could decrease caspase-3 activity and increase the stability of Bcl-2 at the protein level. Our findings illuminate a potential molecular mechanism regarding CAV-1's role as anti-apoptosis protein.

Keywords: :

• Small cell lung cancer
• Caveolin-1
• Apoptosis

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ACKNOWLEDGMENTS

This work was supported by grants from the National Natural Science Foundation of China (No. 81071784 and 20935004), Doctoral Foundation of Ministry of Education of China (No. 20092105110004), and Liaoning Provincial Natural Science Foundation of China (No. 20102056). The authors sincerely appreciate Dr. Barbra Salani from the G. Gaslini Instituto (Italy) for providing the plasmids.