Advanced search
Publication Cover
Cancer Investigation Volume 30, 2012 - Issue 7
Submit an article Journal homepage
158
Views
13
CrossRef citations to date
0
Altmetric
CELLULAR AND MOLECULAR BIOLOGY

Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia

Jutta RiesDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,Correspondence[email protected]
,
Abbas AgaimyInstitute of Pathology, Erlangen University Hospital, Erlangen, Germany,
,
Elefterios VairaktarisDepartment of Oral and Maxillofacial Surgery, University of Athens, Athens, Greece
,
Patricia GoreckiDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,
,
Friedrich W. NeukamDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,
,
Lei H. StraßburgDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,
&
Emeka NkenkeDepartment of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany,
 show all
Pages 495-502 | Accepted 12 Mar 2012, Published online: 31 May 2012
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

The study aimed at checking if MAGE-A expression in oral leukoplakia (OLP) lesions is related to malignant transformation. The 48 samples of OLP that transformed to oral squamous cell carcinoma (OSCC) (group 1) and 50 samples of OLP that did not transform to OSCC (group 2) were included in the study. The expression of MAGE-A was restricted to group 1. The correlation between malignant transformation and MAGE-A occurrence in OLP was statistically significant (p < .0001). Detection of MAGE-A may allow identifying OLP with a high risk of malignant transformation giving a view to a new approach to prevention of oral cancer.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.