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CLINICAL TRANSLATIONAL THERAPUETICS

Biological Response of Nasopharyngeal Carcinoma to Radiation Therapy: A Pilot Study Using Serial 18F-FDG PET/CT Scans

, , , &
Pages 528-536 | Published online: 05 Jun 2012
 

Abstract

We used serial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to evaluate tumors’ maximum standardized uptake value (SUVmax) before, during, and after radiotherapy to explore the biological behavior of and response to radiation therapy in various subtypes of nasopharyngeal carcinoma (NPC). Sixty-one patients with pathologically diagnosed NPC were prospectively enrolled into the study. WHO type IIB disease had a higher initial SUVmax and more significant biological response at the primary site as compared with type IIA subtype. The two subtypes of WHO type II NPC may significantly differ in their biological behavior and response to radiotherapy.

ACKNOWLEDGMENTS

The authors thank Professor Joe, Y. Chang, working in MD Anderson Cancer Center, having reviewed the article. And the authors thank the members and staff of the Departments of Nuclear Medicine and Radiation Oncology of The First Affiliated Hospital of Xiamen University.

DECLARATION OF INTERESTS

The authors report no declarations of interest. This study was supported by grant no. 2008-59-11 from the Major Projects of Fujian Natural Science Foundation and grant no. 2008-1-51 from the Youth Projects of Fujian Provincial Health Bureau.

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