Advanced search
Publication Cover
Cancer Investigation Volume 30, 2012 - Issue 7
Submit an article Journal homepage
484
Views
59
CrossRef citations to date
0
Altmetric
CELLULAR AND MOLECULAR BIOLOGY

Human Bone Marrow-Derived Mesenchymal Stem Cells produced TGFbeta Contributes to Progression and Metastasis of Prostate Cancer

Huamao YeDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China,
,
Jiwen Cheng
,
Yuanjie TangDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China,
,
Zhiyong LiuDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China,
,
Chuanliang XuDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China,
,
Yan Liu
&
Yinghao SunDepartment of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China,Correspondence[email protected]
 show all
Pages 513-518 | Published online: 31 May 2012
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. The expression of MMP-2 and MMP-9 in PC-3 was upregulated by conditional medium of hMSCs. In addition, blocking tumor transformation factor beta (TGFβ) blunted the pro-oncogenic function of hMSCs. These results suggest that hMSCs may play a pro-oncogenic role in the growth of human prostate caner by producing TGFβ.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.