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Cancer Investigation Volume 30, 2012 - Issue 7
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CELLULAR AND MOLECULAR BIOLOGY

Serological Analysis of SEREX-Defined Medullary Breast Carcinoma-Associated Antigens

Olga KostianetsCorrespondence[email protected]
,
Maksym Shyian
,
Demidov SergiyEducational and Scientific Centre “Institute of Biology”, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine,
,
Stepan AntoniukDnipropetrovsk Municipal Clinical Hospital No. 4, Dnipropetrovsk, Ukraine,
,
Ivan GoutDepartment of Structural and Molecular Biology, University College London, London, UK
,
Valeriy FilonenkoDepartment of Cell Signaling, Institute of Molecular Biology and Genetics NAS of Ukraine, The State Key Laboratory of Molecular and Cellular Biology, Kyiv, Ukraine,
&
Ramziya KiyamovaDepartment of Cell Signaling, Institute of Molecular Biology and Genetics NAS of Ukraine, The State Key Laboratory of Molecular and Cellular Biology, Kyiv, Ukraine,
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Pages 519-527 | Published online: 19 Jun 2012
 
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Abstract

Medullary breast carcinoma (MBC) despite anaplastic features and high grade has a good prognosis that can be related to prominent lymphocytic infiltration. We analyzed the frequency of antibody response toward 41 SEREX (serological recombinant expression cloning)-defined MBC antigens in sera of allogeneic MBC patients using serological plaque-spot assay and examined the mRNA expression profile of some antigens in MBC tissues. This preliminary study allowed us to select 18 autoantigens as potential MBC-associated antigens. Further studies in large cohorts of breast cancer patients will be performed for their evaluation as targets for cancer diagnostics or therapy.

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