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Cancer Investigation Volume 30, 2012 - Issue 9
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CELLULAR AND MOLECULAR BIOLOGY

Bortezomib Inhibits the Angiogenesis Mediated by Mesenchymal Stem Cells

Xiaofang WangDepartment of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China,Correspondence[email protected]
,
Zhiqing ZhangDepartment of Neurology, The Fourth Central Hospital of Tianjin, Tianjin, P.R. China,
&
Cheng YaoDepartment of Hematology, Jilin University, Changchun, P.R. China
Pages 657-662 | Published online: 26 Sep 2012
 
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Abstract

This study is to investigate the effects of bortezomib on the angiogenesis of mesenchymal stem cells (MSCs). We examined the effects of bortezomib on the cellular proliferation, migration, and capillary network formation of HUVECs cocultured with CMs of MSCs. We found that Bortezomib inhibited the cellular proliferation and tube formation of HUVECs cocultured with CMs in a dose-dependent fashion. Bortezomib also prevented the migration of HUVECs cocultured with CMs. In addition, bortezomib dose-dependently inhibited the growth of MSCs and prevented the production of angiogenic factors including VEGF (vascular endothelial growth factor), HGF (hepatocyte growth factor), and bFGF (basic fibroblast growth factor) in MSCs. In conclusion, bortezomib prevented the angiogenesis mediated by MSCs.

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