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Cancer Investigation Volume 30, 2012 - Issue 10
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ORIGINAL ARTICLE

TXNDC9 Expression in Colorectal Cancer Cells and Its Influence on Colorectal Cancer Prognosis

Aiguo Lu
,
Xiongzhi WangpuShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,
,
Dingpei HanShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,
,
Hao FengShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,
,
Jingkun Zhao
,
Junjun MaShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,
,
Shun QuShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,
,
Xuehua ChenDepartment of General Surgery, Laiwu City People's Hospital, Laiwu, Shandong Province, China,
,
Bingya LiuShanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
&
Minhua ZhengShanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai, China,Correspondence[email protected]
 show all
Pages 721-726 | Published online: 04 Dec 2012
 
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Abstract

In this study, we analyzed the protein expression of thioredoxin domain containing 9 (TXNDC9) in 116 colorectal cancer (CRC) cases. Among them, 97 were positive in CRC tissues and 60 were positive in normal mucosa. TXNDC9 expression in CRC was correlated with the extent of tumor invasion and the tumor size. TXNDC9-negative patients had longer lifespans. In vitro assays showed the significant suppression of CRC cell proliferation (P < .01) compared with two control groups; the number of invaded cells also decreased (P < .01). These findings suggest that TXNDC9 gene may function in cancer development and may be an effective target for inhibiting the growth and metastasis of CRC cells.

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