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Cancer Investigation Volume 31, 2013 - Issue 9
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ORIGINAL ARTICLE

Comparison Between Gleason Score and Apparent Diffusion Coefficient Obtained from Diffusion-Weighted Imaging of Prostate Cancer Patients

Rocchina CaivanoI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,Correspondence[email protected]
,
Paola RabascoI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Antonella LotumoloI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Patrizia CirilloI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Felice D'AntuonoI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Alexis ZandolinoI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Antonio VillonioI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
,
Luca MacariniUniversity of Foggia, Foggia Italy,
,
Marco Salvatore
&
Aldo CammarotaI.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz),Italy,
 show all
Pages 625-629 | Received 17 Feb 2013, Accepted 05 Sep 2013, Published online: 18 Oct 2013
 
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Abstract

Objectives: To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS). Methods: 40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data. Results: Statistically significant differences of ADC (p < .05) were found among GS groups with a trend of decreasing ADC values with increasing GS. Conclusions: The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.

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