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Abstract
We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participants for 6 weeks. The patients had higher lipid peroxidation (LP) levels in the plasma and erythrocyte samples but lower glutathione peroxidase (GSH-Px) and plasma vitamin E values. In patients treated with BP, calcium and LP levels decreased, but GSH-Px and vitamin E values improved. In conclusion, we observed that treatment with BP alleviated oxidative stress induced by cancer.
ACKNOWLEDGMENTS
MN was responsible for writing the report, whereas MK was responsible for patients, treatments, and blood collection. GK and TTS made critical revisions to the manuscript. The authors are grateful to the technician, Muhammet Şahin for the assistance with blood analysis. The chemical expanses of the current study were partially supported by Dr. Murat Koçer.
| List of Abbreviations | ||
| BP | = | bisphosphonate |
| GSH | = | glutathione |
| GSH-Px | = | glutathione peroxidase |
| MDA | = | malondialdehyde |
| ROS | = | reactive oxygen species |