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Cancer Investigation Volume 32, 2014 - Issue 2
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ORIGINAL ARTICLE

Prognostic Value of p16 Promoter Hypermethylation in Colorectal Cancer: A Meta-Analysis

Wenjie JiangDepartment of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, Shandong Province, ChinaCorrespondence[email protected]
,
Pei-Ge WangDepartment of Emergency General Surgery, The Affiliated Hospital of Qingdao University MedCollege, Qingdao, Shandong Province, China
,
Yuzhu ZhanLaboratory of Cellular and Molecular Biology, Qingdao University Medical College, Qingdao, Shandong Province, China
&
Dongfeng ZhangDepartment of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, Shandong Province, China
Pages 43-52 | Received 15 Aug 2013, Accepted 25 Oct 2013, Published online: 10 Jan 2014
 
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Abstract

Whether or not p16 promoter hypermethylation has any prognostic value on the survival of patients with colorectal cancer (CRC) is uncertain. A meta-analysis was therefore conducted on the overall survival involving 16 studies with 3968 patients and disease-free survival involving six studies with 1091 cases, respectively. The promoter hypermethylation was found to be significantly associated with shorter survival compared to controls, which was not only stable according to influence analysis and cumulative meta-analysis but also conclusive according to trial sequential meta-analysis. The meta-analysis supports the hypermethylation as an independent adverse prognostic factor for CRC.

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