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Cancer Investigation Volume 32, 2014 - Issue 4
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ORIGINAL ARTICLE

Association of Aromatase Inhibitors With Coronary Heart Disease in Women With Early Breast Cancer

B. SerugaSector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaCorrespondence[email protected]
,
V. ZadnikEpidemiology and Cancer Registries, Institute of Oncology Ljubljana, Ljubljana, Slovenia
,
C. Grasic KuharSector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
,
T. MarinkoSector of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia
,
T. CuferDepartment of Oncology, University Clinic Golnik, Golnik, Slovenia
,
B. ZakotnikSector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
,
D. ZormanUniversity Clinical Centre Ljubljana, Ljubljana, Slovenia
,
A. OcanaMedical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain
&
E. AmirDivision of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
 show all
Pages 99-104 | Received 20 Jun 2013, Accepted 24 Dec 2013, Published online: 18 Feb 2014
 
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Abstract

As compared to tamoxifen aromatase inhibitors (AIs) may increase the risk of heart disease. Here we explored the association between the use of AIs and coronary artery disease (CAD) in a population-based observational study. In a small and heterogeneous population of 74 women with early breast cancer who received adjuvant hormonal therapy and subsequently underwent cardiac angiography, AIs significantly increased the hazard for CAD (HR 3.23, 95% confidence intervals [CI] 1.26–8.25, p = .01) compared to tamoxifen. Our results suggest that therapy with AIs may increase the risk for CAD.

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