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Cancer Investigation Volume 32, 2014 - Issue 5
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ORIGINAL ARTICLE

Distribution of Podoplanin-Positive Tumor Vessels Predicts Disease-Specific Survival of Node-Positive Breast Cancer Patients Treated with Anthracyclines and/or Taxanes

Joanna A. NiemiecDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, PolandCorrespondence[email protected]
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Agnieszka AdamczykDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, Poland
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Aleksandra AmbickaDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, Poland
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Anna Mucha-MałeckaDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, Poland
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Wojciech M. WysockiDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, Poland
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Janusz RyśDepartment of Applied Radiobiology, Department of Tumor Pathology, Department of Head and Neck Cancers, Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute, Centre of Oncology, Cracow Branch, Krakow, Poland
Pages 168-177 | Received 06 Jun 2013, Accepted 28 Jan 2014, Published online: 07 Mar 2014
 
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Abstract

We analyzed survival of 102 invasive ductal, node positive breast cancer patients, treated with surgery and adjuvant chemotherapy (anthracyclines and/or taxanes) with relation to: (a) well-known clinicopathological parameters, (b) MIB-1 labeling index (LI), (c) the distribution of podoplanin-positive vessels (DPV), expression of: (d) basal markers, and (e) fascin. Lower progression risk was found for patients with tumors characterized by (i) pN1 + pN2, (ii) MIB-1LI ≤ 28%, (iii) lack of lymphatic vessels or high tumor DPV than for patients with pN3, MIB-1LI > 28%, low DPV, respectively. Cox multivariate analysis revealed that both pN3 and low DPV were negative prognostic indicators.

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