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Cancer Investigation Volume 32, 2014 - Issue 6
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Original Article

PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells

Yun LiDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Jun AnDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Shaohong HuangDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Hongying LiaoDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Yimin WengDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
,
Songwang CaiDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
&
Junhang ZhangDepartment of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaCorrespondence[email protected]
 show all
Pages 236-240 | Received 24 Jan 2014, Accepted 01 Mar 2014, Published online: 25 Apr 2014
 
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Abstract

The apoptotic mechanism dysfunction plays a critical role in cancer cell growth and escaping from cancer therapies; the underlying mechanisms are to be further elucidated. This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells. The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation.

Notice of Correction

Changes have been made to this article since its original online publication date of 25 April 2014.

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