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Cancer Investigation Volume 32, 2014 - Issue 6
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Original Article

SLCO1B1, SLCO2B1, and SLCO1B3 Polymorphisms and Susceptibility to Bladder Cancer Risk

Hoai Thi Thu BuiDepartments of Urology,
,
Naohiro FujimotoDepartments of Urology,Correspondence[email protected]
,
Tatsuhiko KuboPublic Health, School of Medicine, University of Occupational and Environmental Health, Yahatanishi Ward, Kitakyushu, Fukuoka, Japan, and
,
Hisato InatomiDepartment of Urology, Munakata Suikoukai General Hospital, Fukuma-machi, Munakata-gun, Japan
&
Tetsuro MatsumotoDepartments of Urology,
Pages 256-261 | Received 24 Nov 2013, Accepted 18 Mar 2014, Published online: 24 Apr 2014
 
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Abstract

A variety of carcinogens are excreted in urine and may be actively transported by organic anion-transporting polypeptides that encoded by SLCOs. In this study, we evaluated whether single nucleotide polymorphisms (SNPs) in SLCO1B1, SLCO2B1, and SLCO1B3 are associated with bladder cancer susceptibility. Our results, for the first time, indicated that polymorphisms of SLCO1B1 rs2306283 might be associated with bladder cancer risk. Therefore, SNPs in SLCO1B1 may be potential biomarkers for assessing the risk of bladder cancer.

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