Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis

Abstract

To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted a meta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphism was associated with cancer risk in the pooled analysis and in Asian population, whereas no association was observed in Caucasian population. Stratified analysis by subtypes of cancer showed that the -94ins/del polymorphism was associated with oral squamous cell carcinoma and ovarian cancer risk, but had no association with colorectal cancer, bladder cancer, and renal cell cancer. Our meta-analysis suggests the NFKB1 -94ins/del polymorphism affects cancer susceptibility, and the association is ethnic-specific.

Keywords: :

• Cancer genetics
• Carcinogenesis
• Risk and prevention

ACKNOWLEDGMENTS

The authors are grateful to all the people who provided help for this study. This work was supported by the grants from the 973 Program (2012CB910103).