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Cancer Investigation Volume 32, 2014 - Issue 8
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Article

Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer

Wang-Yu ZhuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Bin LuoDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Ji-yuan AnInstitute of Digital Agriculture, Zhejiang Academy of Agricultural sciences, Hangzhou, Zhejiang, China
,
Jian-ying HeDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Dong-dong ChenDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Li-Yun XuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Yan-Yan HuangDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Xiao-Guang LiuDepartment of The Joint Laboratory of Immunogenomics, Zhoushan Hospital-BIG/CAS, Zhoushan Hospital, Zhoushan, Zhejiang, China,
,
Han-bo LeDepartment of Cardio-Thoracic Surgery, Zhoushan Hospital, Zhoushan, Zhejiang, China,
&
Yong-Kui ZhangDepartment of Cardio-Thoracic Surgery, Zhoushan Hospital, Zhoushan, Zhejiang, China,Correspondence[email protected] [email protected] [email protected]
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Pages 394-401 | Received 31 Mar 2013, Accepted 06 May 2014, Published online: 19 Jun 2014
 
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Abstract

Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.

Notice of Correction

Changes have been made to this article since its original online publication date of 19 June 2014.

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