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Cancer Investigation Volume 32, 2014 - Issue 8
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Article

MKK6 is Upregulated in Human Esophageal, Stomach, and Colon Cancers

Arif Ali ParrayDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Rafia Anjum BabaDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Hina Fayaz BhatDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Lateef WaniDepartment of Pathology, Shri Maharaja Hari Singh Hospital, Srinagar, Jammu and Kashmir, India
,
Taseem Ahmad MokhdomiDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Umar MushtaqDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Sehar Saleem BhatDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Deeba KirmaniDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India
,
Sanaullah KuchayDepartment of Radiation Oncology, Shri Maharaja Hari Singh Hospital, Srinagar, Jammu & Kashmir, India
,
Mudassir Maqbool WaniDepartment of Surgery, King Khalid University, Abha Campus, Saudi Arabia
&
Firdous Ahmad KhandayDepartment of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, IndiaCorrespondence[email protected]
 show all
Pages 416-422 | Received 26 Jul 2013, Accepted 06 Jun 2014, Published online: 14 Jul 2014
 
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Abstract

Expression analysis of MKK6 protein in solid tumors has never been investigated. Here, we report systematic analysis of MKK6 protein in different types of human tumor samples using western blotting and immunofluorescence techniques. We observed significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls. Results were alternately confirmed by Immunofluorescence studies. Upregulation of MKK6 protein is indicative of its role in human cancers and could possibly be used as a novel diagnostic or prognostic marker in these cancers.

Notice of Correction

Changes have been made to this article since its original online publication date of 14 July 2014.

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