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Cancer Investigation Volume 33, 2015 - Issue 8
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ORIGINAL ARTICLE

Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer

Jens NeumannInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, GermanyCorrespondence[email protected]
,
Lisa LöhrsDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany
,
Markus AlbertsmeierDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany
,
Simone ReuInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany
,
Markus GubaDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany
,
Jens WernerDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany
,
Thomas KirchnerInstitute of Pathology, Ludwig-Maximilians-Universität München, Munich, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany
&
Martin AngeleDepartment of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Medical Center of the University of Munich, Munich, Germany
 show all
Pages 354-360 | Received 21 Jan 2015, Accepted 29 Apr 2015, Published online: 12 Jun 2015
 
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Abstract

Although peritoneal carcinomatosis (PC) displays advanced stage in colorectal cancer (CRC), most patients present without distant metastases. To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and β-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread. Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC. Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC. These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination.

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