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Cancer Investigation Volume 33, 2015 - Issue 10
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ORIGINAL ARTICLE

Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors

Beatrice RubinDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, ItalyCorrespondence[email protected]
,
Halenya MonticelliDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Marco RedaelliDepartment of Molecular Medicine, University of Padua, Padua, Italy
,
Carla MucignatDepartment of Molecular Medicine, University of Padua, Padua, Italy
,
Susi BarolloDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Loris BertazzaDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Caterina MianDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Corrado BetterleDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Maurizio IacoboneDivision of Minimally Invasive Endocrine Surgery, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
,
Ambrogio FassinaDivision of Pathology and Cytopathology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Marco BoscaroDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
,
Raffaele PezzaniDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
&
Franco ManteroDivision of Endocrinology, Department of Medicine (DIMED), University of Padua, Padua, Italy
 show all
Pages 526-531 | Received 07 Apr 2015, Accepted 27 Jul 2015, Published online: 04 Nov 2015
 
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Abstract

Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no concrete data confirming alteration rate. The objective of this study was to evaluate genetic alterations in key components of MAPK pathway. We found one BRAF mutation (p.V600E) and four HRAS silent mutations. No alteration was found in NRAS, KRAS, EGFR genes. The patient carrying BRAF mutation was further characterized by investigating his biomolecular and clinico-pathological findings. Therefore, even if MAPK signaling is activated in ACT, our results suggest that genetic alterations do not seem to represent a frequent mechanism of ACT tumorigenesis.

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