Advanced search
Publication Cover
Cancer Investigation Volume 34, 2016 - Issue 3
Submit an article Journal homepage
163
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

High Expression of Cullin7 Correlates with Unfavorable Prognosis in Epithelial Ovarian Cancer Patients

Jie XiDepartment of Gynecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, China
,
Sai-tian ZengDepartment of Gynecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaCorrespondence[email protected]
,
Liang GuoDepartment of Gynecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, China
&
Jing FengDepartment of Gynecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, China
Pages 130-136 | Received 16 Jun 2015, Accepted 22 Oct 2015, Published online: 10 Mar 2016
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal ovarian surface tissues. In addition, Cullin7 expression was related to FIGO stage (p = .001) and lymph node metastasis (p = .033). Furthermore, Cullin7 overexpression inhibited the migration and invasion of ovarian cancer cells. These results suggest that Cullin7 may serve as an indicator of poor prognosis in patients with EOC.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.