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Cancer Investigation Volume 34, 2016 - Issue 3
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Original Articles

Radiation Duration in Women with Cervical Cancer Treated with Primary Chemoradiation: A Population-Based Analysis

Ana I. TergasDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USACorrespondence[email protected]
,
Alfred I. NeugutDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA;Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
,
Ling ChenDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
,
William M. BurkeDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
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Dawn L. HershmanDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA;Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
&
Jason D. WrightDepartment of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Pages 137-147 | Received 02 Jun 2015, Accepted 09 Dec 2015, Published online: 17 Mar 2016
 
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ABSTRACT

This study examines factors associated with prolonged radiation duration and its impact on survival in women with cervical cancer treated with primary chemoradiation. Women in the National Cancer Database with stage IB2-IVA cervical cancer from 2003 to 2011 who received radiation and chemotherapy were included. Of 7209 women, who met inclusion criteria, 3401 (47.1%) and 3808 (52.8%) completed radiation in ≤ 8 and > 8 weeks, respectively. There was no overall survival difference for radiation duration ≤ 8 vs. > 8 weeks. Sensitivity analyses showed that inferior overall survival is only seen with radiation duration of > 10–12 weeks.

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