Taxanes: A New Class of Antitumor Agents

M. T. Huizing Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Medical Oncology, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands; Department of Medical Oncology, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

V. H. Sewberath Misser Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands

R. C. Pieters Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

W. W. ten Bokkel Huinink Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

C. H. N. Veenhof Department of Medical Oncology, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

J. B. Vermorken Department of Medical Oncology, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

H. M. Pinedo Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Medical Oncology, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

J. H. Beijnen Department of Pharmacy, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

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Abstract

Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes.

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Taxanes: A New Class of Antitumor Agents

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Taxanes: A New Class of Antitumor Agents

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