Tumor Necrosis Factor as Marker for Monocyte Function in Chronic Myeloid Leukemia

V. S. Chitnis Division of Laboratory Medicine and Department of Medical Oncology, Tata Memorial Hospital, Bombay, 400012, India

P. M. Parikh Division of Laboratory Medicine and Department of Medical Oncology, Tata Memorial Hospital, Bombay, 400012, India

J. S. Nadkarni Division of Laboratory Medicine and Department of Medical Oncology, Tata Memorial Hospital, Bombay, 400012, India

V. C. Kulkarni Division of Laboratory Medicine and Department of Medical Oncology, Tata Memorial Hospital, Bombay, 400012, India

S. H. Advani Division of Laboratory Medicine and Department of Medical Oncology, Tata Memorial Hospital, Bombay, 400012, India

Abstract

The intactness of monocyte function in chronic myeloid leukemia (CML) patients as assessed by their ability to secrete tumor necrosis factor was evaluated. Monocytes from CML patients continued to respond to lipopolysaccharide (LPS) stimulation even during the refractory period, suggesting different pathways for stimulation by LPS and malignant processes.

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Tumor Necrosis Factor as Marker for Monocyte Function in Chronic Myeloid Leukemia

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Tumor Necrosis Factor as Marker for Monocyte Function in Chronic Myeloid Leukemia

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