Advanced search
Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 32, 2015 - Issue 2
Submit an article Journal homepage
350
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Circadian rest/activity rhythms in knee osteoarthritis with insomnia: A study of osteoarthritis patients and pain-free controls with insomnia or normal sleep

Adam P. SpiraDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, ;Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and Correspondence[email protected]
,
Virginia T. RunkoDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
,
Patrick H. FinanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
,
Christopher N. KaufmannDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA,
,
Sara C. BoundsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
,
Lianqi LiuDepartment of Psychiatry, University of California, San Diego, CA, USA
,
Luis F. BuenaverDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
,
Lea M. McCauleyDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
,
Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, CA, USA
&
Michael T. SmithDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA, and
show all
Pages 242-247 | Received 10 Jun 2014, Accepted 08 Sep 2014, Published online: 07 Oct 2014
 
Sample our Behavioral Sciences journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Aberrant circadian rest/activity rhythms (RARs) may promote poor aging-related health outcomes. Osteoarthritis and chronic insomnia are common age-related conditions, but the circadian RARs of each group have not been well characterized or compared. We evaluated actigraphic RARs in individuals with: (1) knee osteoarthritis (KOA) only; (2) chronic insomnia only; (3) KOA + insomnia; and (4) pain-free good sleepers. Compared to participants with KOA only, those with KOA + insomnia had less robust RARs. There were no differences between other groups. Further research is needed to evaluate whether aberrant RARs contribute to arthritis symptoms and insomnia in KOA, and whether strengthening RARs ameliorates arthritis symptoms.

Declaration of interest

This research was supported by the National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS) grants 5R01AR054871 and 5R01AR059410.

Dr. Adam Spira is supported by a Mentored Research Scientist Development Award (1K01AG033195) from the National Institute on Aging.

Dr. Runko is employed by the Johns Hopkins Center for Sleep, Columbia, MD and The Ross Center for Anxiety and Related Disorders in Washington, DC.

Mr. Kaufmann is supported by an Individual National Research Service Award (F31AG044052) from the National Institute on Aging.

Dr. Lianqi Liu is supported by an NIH grant R21 CA158954-01A1.

Dr. Ancoli-Israel is a consultant for Acadia, Actelion, Arena, Astra Zeneca, Merck, NeuroVigil, Inc., Otsuka.

Dr. Michael Smith holds an equity stake in BMED Technologies, which develops self-help materials for behavioral disorders, including insomnia. Potential conflicts related to this interest are managed by the Johns Hopkins University Conflict of Interest Office.

Data from this study were presented at the 2012 meeting of the Associated Professional Sleep Societies, Boston, MA.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 489.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.