Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in TALLYHO/JngJ mice

ABSTRACT

Studies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model –TALLYHO/JngJ – and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.

KEYWORDS:

• Advance
• jet-lag
• mouse
• shift-work
• TALLYHO/JngJ
• type-2 diabetes

Declaration of interest

The authors declare no competing financial interests.

Supplementary material available online

Supplementary Figures 1–3.

Acknowledgements

The authors would like to thank Nicole Arruda, Isabella De Pina Monteiro, Rachel Gelineau, Gina Nash, Dylon Pyne and Josh West for their help with animal maintenance and weekly measurements.