Outcome After High-Dose Radioiodine Therapy for Advanced Differentiated Thyroid Carcinoma in Childhood

Abstract

Objective. To evaluate the clinical outcome in childhood patients receiving postoperative high-dose radioiodine therapy for advanced differentiated thyroid carcinoma. Method. Patients under 18 years old with neck diseases (n = 4) or distant metastases (n = 10) received postoperative radioiodine ablation and repeated treatments for a median of 2 (0.8˜10) years with an averaged activity of 25.0 (7.0˜72.2) GBq. Results. Partial remission was achieved in 6, stable disease in 6 and progressive disease in 2 patients, without severe side effects except for two Grade 1 and one Grade 2 WHO haematological toxicity. The median survival time from diagnosis to the last treatment sessions was 5.3 (range, 0.7˜14.5) years. Conclusion. High-dose radioiodine treatment was well tolerated with satisfactory outcome in childhood patients with advanced differentiated thyroid carcinoma.

Keywords:

• Childhood Thyroid Carcinoma
• Radioiodine
• Side Effect
• Therapeutic Efficacy