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Abstract
Neuropsychiatric Manifestations of Systemic Lupus Erythematosus (SLE).
The literature on psychiatric and neurological manifestations in SLE is discussed. Five cases are reported. The psychiatric picture is in accordance with the known classification of organic mental syndromes.
The differential diagnosis to non-organic psychosis depends on the demonstration of SLE. The symptomatology does not permit differenation to psychosis induced by steroids. If a patient suffering from SLE during treatment with steroids develops a psychotic episode, it is most likely caused by SLE-involvement of the central nervous system. Neuropsychiatric abnormality of SLE may be the initial or single manifestation of SLE.
Reservation with pharmacological treatment of the neuropsychiatric symptoms is warranted by possible aggravation of SLE by several medicaments.
In 3 of our 5 patients we noticed medicamental provocation during treatment with chlorprotixen, chlorpromazin and phenytoin.