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Abstract
The sera of horses with persistent infection by equine infectious anemia virus were examined for the presence of infectious virus-antibody complexes, Virus-containing sera were treated with rabbit anti-equine gamma globulin, rabbit anti-equine albumin, and normal rabbit serum. Infectivity remaining in the supernates was titrated in primary equine leukocyte cultures. In 2 of 3 sera anti-gamma globulin precipitated at least 2 log10 of viral infectivity using the anti-albumin and normal rabbit serum treatments as controls. This demonstrates that in some sera EIA virus circulates as an immune complex with antibody, possibly enhancing its ability to persist in the host by providing a continued source of virus for reinfection.