Inhibition of association vs. dissociation of high-avidity DNA/Anti-DNA Conplexes: Possible involvement of secondary hydrogen bonds

C. J. Van Oss Department of Microbiology and Department of Chemical Engineering, State University of New York at Buffalo, Buffalo, New York, 14214, USA

K. J. T. Smeenk Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, P.O. Box 9190, 1006 AD, Amsterdam, The Netherlands

L. A. Aarden Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, P.O. Box 9190, 1006 AD, Amsterdam, The Netherlands

Abstract

Recent results on the conditions of ionic strength needed to prevent the association of dsDNA with high avidity human anti-dsDNA, were compared with the insufficiency of even the highest practicable ionic strengths to effect the dissociation of such antigen-antibody complexes, once formed (1). Further analysis of these results make us conclude that such high avidity dsDNA-anti-dsDNA complexes. which in the initial stages of their formation are mainly of the Coulombic variety. subsequently evolve, at least in part, into hydrogen bonds.

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Inhibition of association vs. dissociation of high-avidity DNA/Anti-DNA Conplexes: Possible involvement of secondary hydrogen bonds

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Inhibition of association vs. dissociation of high-avidity DNA/Anti-DNA Conplexes: Possible involvement of secondary hydrogen bonds

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