Association Between CD24-P226-C/T Polymorphism and Multiple Sclerosis: A Meta-Analysis

Abstract

Background: Multiple sclerosis (MS) is a progressive inflammatory and neurodegenerative disease of the central nervous system (CNS), the etiology of which is still uncertain. Several case-control studies investigated the association between CD24-P226-C/T polymorphism and MS risk, and these studies have shown inconsistent results.

Objective: To address the association of CD24-P226-C/T polymorphism with MS risk by meta-analysis.

Methods: A comprehensive search was conducted to identify all eligible studies of CD24-P226-C/T polymorphism and MS risk up to July 2013. The odds ratios (ORs) of CD24 allele distributions in MS were analyzed against controls.

Results: In total, seven case-control studies with 949 cases of MS and 1177 controls were included in this meta-analysis. The overall results showed a significant association between CD24-P226-C/T polymorphism and MS susceptibility under homozygote comparison model (OR = 2.496, 95% CI = 1.813–3.435, p < 0.0005), dominant model (OR = 1.367, 95% CI = 1.147–1.629, p < 0.0005), recessive model (OR = 2.305, 95% CI = 1.700–3.126, p < 0.0005) and allelic model (OR = 1.422, 95% CI = 1.244–1.625, p < 0.0005). However, no significant association was observed under heterozygous comparison model (OR = 1.182, 95% CI = 0.982–1.423, p = 0.078).

Conclusions: This meta-analysis indicates that CD24 P266-C/T polymorphism is more associated with the risk of MS than healthy controls. However, due to the small sample size in most of the included studies, additional large-scale and well-designed case-control studies were required for the validation of this association.

• Gene polymorphism
• meta-analysis
• multiple sclerosis
• TCF7L2

Acknowledgements

This study was supported by grants from Science and Technology Program of Shenyang (No. F12-148-9-00); this study was also supported in part by the National Natural Science Foundation of China (No. 81173092), and Liaoning Provincial Science and Technology Program (No. 2011415052).

Declaration of interest

The authors declare that they have no conflicts of interest. LJ and MW conceived and designed the experiments; LJ and XB performed the experiments; LJ and YW analyzed the data; YW contributed reagents/materials/analysis tools; and, JL and MW wrote the paper. The funders had no roles in study design, data collection and analysis, decision to publish, or preparation of the manuscript.