BCG Specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent ppd reactive cells

H. Mejía-López Departarnentos de Microbiología-Parasitología, Facultad de Medicina UNAM, México, D F, 04510

L. G. Martínez-García Departarnentos de Microbiología-Parasitología, Facultad de Medicina UNAM, México, D F, 04510

E. Zenteno Departarnentos de Bioquímica, Facultad de Medicina UNAM, México, D F, 04510

M. A. Salazar Instituto Nacional de Enfermedades Respiratorias, México

M. Selman Instituto Nacional de Enfermedades Respiratorias, México

M. L. Taylor Departarnentos de Microbiología-Parasitología, Facultad de Medicina UNAM, México, D F, 04510

Abstract

The effect of tuberculosis anergic immune sera adsorbed with BCG was studied on cocultures of adherent and non-adherent cells from PPD⁺ tuberculosis patient (TBP PPD⁺). This effect on the cocultures was quantified by lymphocyte transformation (LT) test using PPD as antigen. Only those cocultures with non-adherent cells from TBP PPD⁺ patients treated with anergic sera, inhibited the LT response induced by PPD, whereas sera adsorption with BCG eliminated the inhibitory effect.

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BCG Specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent ppd reactive cells

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BCG Specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent ppd reactive cells

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