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Reviews

Lipofuscin and the Principles of Fundus Autofluorescence: A Review

, &
Pages 197-201 | Received 05 Jul 2012, Accepted 09 Jul 2012, Published online: 19 Nov 2012
 

Abstract

Fundus autofluorescence is a non-invasive imaging modality that measures lipofuscin that has accumulated in the retinal pigment epithelium (RPE). Excessive lipofuscin in the RPE is a common pathway found in several diseases including Stargardt’s disease and age-related macular degeneration. This review discusses the role of photooxidative damage in the development of lipofuscin and the principles of fundus autofluorescence.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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