Management of Cataracts and Oculo-Cutaneous Malignancy in Xeroderma Pigmentosum

ABSTRACT

This case report describes the management of a 17-year-old woman with xeroderma pigmentosum (XP) with bilateral mature cataract, conjunctival squamous cell carcinoma in the left eye (OS) and a cutaneous squamous cell carcinoma on her nose. To our knowledge, this is the first reported XP case with a cataract developing in the last couple of years without any ocular trauma, any history of inadequate diet or of previous corticosteroid use. We believe that cataracts can be related to improper working of the DNA repair mechanism of the lens epithelial cells in XP patients.

• Xeroderma pigmentosum
• cataract
• amniotic membrane transplantation
• conjunctival squamous cell carcinoma
• mitomycin C

Acknowledgements

The authors are grateful to Prof. Dr. Christopher J. Rapuano for his comments and generous support in the review of the case report.