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Seminars in Ophthalmology Volume 28, 2013 - Issue 5-6: Genetic Advances in Ophthalmology
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Research Article

The Role of Genetics in the Pathogenesis of Periocular Cutaneous Neoplasms: Implications for Targeted Therapy

Nahyoung Grace LeeDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MassachusettsUSACorrespondence[email protected]
,
Leo A. KimDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MassachusettsUSA
&
Suzanne K. FreitagDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston MassachusettsUSA
Pages 267-274 | Received 19 Apr 2013, Accepted 11 Jul 2013, Published online: 18 Oct 2013
 
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Abstract

In the past, cutaneous malignancies of the periocular region were primarily treated surgically with few other options. As the genetic bases of these tumors have become elucidated, targeted therapies aimed specifically at pathways that are felt to be responsible for cellular proliferation and uncontrolled growth have emerged with new promise. This review contains a summary of the various genetic implications of cutaneous neoplasms as well as their corresponding targeted systemic therapies.

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