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International Reviews of Immunology Volume 30, 2011 - Issue 2-3
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Research Article

Understanding the Cross-Talk between Ovarian Tumors and Immune Cells: Mechanisms for Effective Immunotherapies

Maurizio Chiriva-InternatiDepartment of Internal Medicine at Division of Hematology/Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas, USA, and Laura W. Bush Institute for Women's Health and Center for Women's Health, Texas Tech University Health Sciences Center, Amarillo, Texas, USACorrespondence[email protected]
,
Leonardo MirandolaDepartment of Internal Medicine at Division of Hematology/Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas, USA, and Laura W. Bush Institute for Women's Health and Center for Women's Health, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
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W. Martin KastDepartments of Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA; Obstetrics & Gynecology and Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA; and Cancer Research Center of Hawaii, University of Hawaii at Manao, Honolulu, Hawaii, USA
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Marjorie R. JenkinsDepartment of Internal Medicine at Division of Hematology/Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas, USA, and Laura W. Bush Institute for Women's Health and Center for Women's Health, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
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Everardo CobosDepartment of Internal Medicine at Division of Hematology/Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas, USA, and Laura W. Bush Institute for Women's Health and Center for Women's Health, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
&
Martin J. CannonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Pages 71-86 | Published online: 10 May 2011
 
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Abstract

Despite decades of research, ovarian cancer remains a lethal disease. Recent studies have reported the critical role played by the immune system in controlling growth and spread of ovarian tumors. Accordingly, immunotherapy has been indicated as the most likely successful new approach in the treatment of the disease. Unfortunately, ovarian cancer triggers immune inhibitory mechanisms that hamper anti-tumor responses. Therefore, future immunotherapies should be able to overcome these obstacles. Here we review the basic mechanisms of tumor immune surveillance with a particular focus on ovarian cancer, and we discuss cutting-edge strategies to promote immune system eradication of ovarian tumors.

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