Regulation of T-cell Responses and Disease by Tec Kinase Itk

Abstract

Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8⁺ innate memory phenotype T cells, different γδ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.