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International Reviews of Immunology Volume 33, 2014 - Issue 3: Immunology of Transplantation
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REVIEW

Immunosenescence and Immune Response in Organ Transplantation

Paulo Ney Aguiar MartinsDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
,
Stefan G. TulliusDivision of Transplantation, Department of Surgery, Brigham and Women Hospital, Harvard Medical School, Boston, MA, USA
&
James F. MarkmannDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Pages 162-173 | Accepted 14 Jul 2013, Published online: 15 Oct 2013
 
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Abstract

The immune system undergoes a complex and continuous remodeling with aging. Immunosenescence results into both quantitative and qualitative changes of specific cellular subpopulations that have major impact on allorecognition and alloresponse, and consequently on graft rejection and tolerance. Here, we are going to review the immunological changes associated with the aging process relevant for transplantation. Interventions to selectively target changes associated with the senescence process seem promising therapeutic strategies to improve transplantation outcome.

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