Dear editor,
We read with great interest the recently published article in the esteemed Journal of Renal Failure, by Lim et al., entitled “C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice”.Citation1 They aimed to investigate protective role of C-phycocyanin, one of the active ingredients of Spirulina, against cisplatin-induced nephrotoxicity. They found that C-phycocyanin ameliorates cisplatin-induced nephrotoxicity.Citation1 In this study, we like to mention some points about cisplatin renal toxicity. In an experimental study on 27 ovariectomized female rats, we established that estrogen attenuates defending property of erythropoietin against cisplatin-induced renal toxicity in ovariectomized rats.Citation2 Also, to study the protective properties of .-arginine on cisplatin-induced kidney toxicity, we found that .-arginine had protective effect on cisplatin-induced renal toxicity in male rats; however, it intensifies the induced damage in female Wistar rats. In this study, we concluded a gender-related difference in rat model of cisplatin renal toxicity.Citation3 In another study, we observed that losartan as an angiotensin receptor blocker could attenuate cisplatin kidney toxicity in male rats, while it aggravates the cisplatin kidney injury in female rats.Citation4 We concluded that gender difference of cisplatin renal toxicity was related to the renin--angiotensin system receptors in the kidneys.Citation4–9 Moreover, we recently found that vitamin C, vitamin E, or losartan have no ameliorative effects against cisplatin-kidney toxicity in presence of estrogen in ovariectomized rat model of cisplatin toxicity,Citation10 which is in agreement with our previous findings too. Hence, it is well established that there is a gender difference in the cisplatin renal toxicity in rat model. Indeed, it is well recognized that some conditions that lead to chronic kidney diseases are sex related too;Citation5–9,Citation11–13 however, few studies published regarding gender difference in cisplatin renal toxicity. However, there still needs to be more investigations, mechanisms take part in cisplatin renal toxicity especially on gender difference.Citation10,Citation14 In this regard, to better understand the factor of gender difference in cisplatin nephrotoxicity, further preclinical rat model or clinical studies are recommended.
Declaration of interest
The authors declared no competing interests.
References
- Lim BJ, Jeong JY, Chang YK, et al. C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice. Ren Fail. 2012;34(7):892–900
- Pezeshki Z, Nematbakhsh M, Mazaheri S, et al. Estrogen abolishes protective effect of erythropoietin against cisplatin-induced nephrotoxicity in ovariectomized rats. ISRN Oncol. 2012;2012:890310. DOI:10.5402/2012/890310
- Eshraghi-Jazi F, Nematbakhsh M, Nasri H, et al. The protective role of endogenous nitric oxide donor (.-arginine) in cisplatin-induced nephrotoxicity: gender related differences in rat model. J Res Med Sci. 2011;16(11):1389–1396
- Haghighi M, Nematbakhsh M, Talebi A, et al. The role of angiotensin II receptor 1 (AT1) blockade in cisplatin-induced nephrotoxicity in rats: gender-related differences. Ren Fail. 2012;34(8):1046–1051
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