Effector and regulatory roles For B cells in HIV infection?

Abstract

Toll-like receptor (TLR) signaling has been implicated in the genesis of HIV driven chronic immune activation and inflammation. In other inflammatory diseases, TLR driven B cell regulatory functions have been described, yet in HIV pathogenesis the focus has been on an antibody-dependent role for B cells. In this review, we discuss possible effector and regulatory functions exerted by (TLR) activated B cells during HIV infection.

Keywords::

• Regulatory B cells
• Toll-like Receptor
• Microbial Translocation
• Chronic Immune Activation
• Proinflammatory Cytokines
• Immune Exhaustion
• Chemokines
• IL-10

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.