Advanced search
Publication Cover
Immunopharmacology and Immunotoxicology Volume 33, 2011 - Issue 1
Submit an article Journal homepage
87
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Monocyte-induced NK cell inactivation: role of reactive oxygen and nitrogen metabolites

Mei-Zhu ZhengDepartment of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China
,
Hong-Da PanWest China Center of Medical Sciences, Sichuan University, Renmin South Road, Chengdu 610044, Sichuan, China
,
Jing-Xin PanDepartment of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, ChinaCorrespondence[email protected]
&
Jian-Xin GuoDepartment of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China
Pages 150-156 | Received 28 Sep 2009, Accepted 23 Apr 2010, Published online: 01 Jun 2010
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Here in a co-cultivation system of natural killer (NK) cells and K562 cells, monocytes (MO) and/or interleukin (IL)-2/phytohemagglutinin (PHA) were administered. After MO were administered, reactive oxygen metabolites (ROM)/reactive nitrogen metabolites (RNM) productions increased, while tumor necrosis factor (TNF)-β/interferon (IFN)-γ levels and NK cell cytotoxicity (NCC) decreased, the changes of which after administering tiopronin (TIP) or glutamylcysteinylglycine (GSH) were opposite. In conclusions, the activated MO could inhibit the NK cell activity to kill K562 cell by secreting ROM and RNM. And TIP and GSH could scavenge both ROM and RNM to reverse the inhibitory effect of MO.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,339.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.