Prolyl hydroxylase and hypoxia inducible factor: potential targets for cancer therapy

Abstract

Prolyl hydroxylase (PHD) is one of the major enzymes that play a key role in metastasis and angiogenesis. PHD regulates tumor progression by the degradation of hypoxia inducible factor-α (HIF-α), an important factor associated with angiogenesis. This review will provide an overview of the role of PHD and HIF in tumor progression and how it can serve as potential targets for cancer therapy

Keywords::

• Prolyl hydroxylase
• HIF
• cancer therapy

Acknowledgement

The valuable help of Dr. V.M. Berlin Grace, Head, Department of Biotechnology and Dr. M. Patrick Gomez, Director, School of Biotechnology and Health Sciences is gratefully acknowledged.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.