Inhibitory effects of organic solvent extracts from Korean local plants on the complement classical pathway

Abstract

The study evaluated the anticomplement effects from organic solvent extracts of five Compositae plants (Ligularia fischeri (Ledeb.) Turez, Ligularia taquetii (H.Lev. & Vaniot) Nakai, Ainsliaea acerifolia Sch.Bip, Aster scaber Thunb, Aster koraiensis Nakai, Synurus deltoides Aiton) from South Korea on the classical pathway complement system. We have evaluated organic solvent extracts from five Compositae with regard to its anticomplement activity. Chloroform extracts from L. taquetii showed inhibitory activity against complement system with 50% inhibitory concentrations (IC₅₀) values of 73.2 μg/mL. This is the first report of anticomplement activity from L. taquetii.

Keywords::

• Compositae
• anticomplement activity
• classical pathway
• Ligularia taquetii
• local

Disclosure of interest

This study was supported by research funds from Dong-A University.