Anticomplement activity of various solvent extracts from Korea local Artemisia spp.

Abstract

The study evaluated the anticomplement activity from various solvent extracts of eight Artemisia plants (Artemisia capillaris Thunb., Artemisia fukudo Makino., Artemisia japonica Thunb., Artemisia montana (Nakai) Pamp., Artemisia keiskeana Miq., Artemisia rubripes Nakai., Artemisia stolonifera (Maxim.) Kom., and Artemisia sylvatica Max.) from South Korea on the classical pathway (CP). We have evaluated various organic solvent extract from eight Artemisia plants with regard to its anticomplement activity on the CP. A. rubripes and A. montana chloroform extracts showed inhibitory activity against complement system with 50% inhibitory concentrations (IC₅₀) values of 54.3 and 64.2 μg/mL. This is the first report of anticomplement activity from Artemisia plants.

Keywords::

• Artemisia
• Artemisia rubripes Nakai.
• Artemisia montana (Nakai) Pamp.
• anticomplement activity
• classical pathway