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Immunopharmacology and Immunotoxicology Volume 35, 2013 - Issue 6
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Review Article

Potential for novel MUC1 glycopeptide-specific antibody in passive cancer immunotherapy

Caroline B. MadsenDepartment of Cellular and Molecular Medicine, Copenhagen Center for Glycomics;Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen CopenhagenDenmark
,
Hans H. WandallDepartment of Cellular and Molecular Medicine, Copenhagen Center for Glycomics
&
Anders Elm PedersenDepartment of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen CopenhagenDenmarkCorrespondence[email protected]
Pages 649-652 | Received 25 Mar 2013, Accepted 16 Aug 2013, Published online: 24 Sep 2013
 
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Abstract

MUC1 is an important target for antibodies in passive cancer immunotherapy. Antibodies against mucin glycans or mucin peptide backbone alone may give rise to cross reactivity with normal tissues. Therefore, attempts to identify antibodies against cancer-specific MUC1 glycopeptide epitopes havebeen made. We recently demonstrated that a monoclonal antibody against the immunodominant Tn-MUC1 (GalNAc-α-MUC1) antigen induced ADCC in breast cancer cell lines, suggesting the feasibility of targeting combined glycopeptide epitopes in future passive cancer immunotherapy.

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