In Vitro Effects of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (RhGM-CSF) on Polymorphonuclear Cell (PMN) and Monocyte (MO) Functional Capacities in Ovarian Cancer Patients Versus Human Volunteers

M. Altamura Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

M. G. Geronimo Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

M. Pepe Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

P. Lella Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

L. Nappi Institute of Obstetrics and Gynecology II, University of Bari Medical School, Bari, Italy

P. Loizzi Institute of Obstetrics and Gynecology II, University of Bari Medical School, Bari, Italy

M. Forte Institute of Obstetrics and Gynecology II, University of Bari Medical School, Bari, Italy

M. Marsilio Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

G. Piazzolla Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

S. Antonaci Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

E. Jirillo Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Bari, Italy

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Abstract

Human polymorphonuclear cells (PMN) and monocytes (MO) from four ovarian cancer patients and seventeen normal donors were in vitro pretreated with different concentrations (25, 50 and 100IU, respectively) of rhGM-CSF. Phagocytosis and killing of PMN and MO as well as PMN polarization were evaluated in cancer patients before treatment (T0) and at the end of each chemotherapeutic cycle (T1, T2, T3 and T4, respectively) in comparison with normal donors. RhGM-CSF did not affect phagocytosis and killing of PMN and MO. On the other hand, this cytokine was per se endowed with the capacity to enhance PMN polarization in both cancer patients (at T2 interval) and normal donors.

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In Vitro Effects of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (RhGM-CSF) on Polymorphonuclear Cell (PMN) and Monocyte (MO) Functional Capacities in Ovarian Cancer Patients Versus Human Volunteers

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In Vitro Effects of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (RhGM-CSF) on Polymorphonuclear Cell (PMN) and Monocyte (MO) Functional Capacities in Ovarian Cancer Patients Versus Human Volunteers

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