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ORIGINAL RESEARCH

Biodistribution of Technetium-99m Pertechnetate after Total Gastrectomy and Roux-en-Y Jejunal Pouch

, , MD, , , PhD, , PhD & , PhD
Pages 94-100 | Received 26 Feb 2009, Accepted 23 Jun 2009, Published online: 24 May 2010
 

ABSTRACT

This paper investigates the influence of total gastrectomy, with and without a jejunal pouch, on the biodistribution of the radiopharmaceutical Technetium-99m pertechnetate (99mTcO4). A quantitative biodistribution study was performed on the 30th postoperative day in Wistar rats, using the Wizard PerkinElmer gamma counter. The percentage of injected radioactivity of 99mTcO4 per gram of tissue (% ATI/g) in Roux-en-Y total gastrectomy rats was lower in the lung, brain, and femur, compared to the sham rats (p <.05). In the jejunal pouch rats, the%ATI/g was higher than in the jejunum of sham rats (p <.05). The biodistribution was higher in the lung, brain, and femur of Roux-en-Y pouch rats than in Roux-en-Y rats (p <.05). Serum levels of cobalamin, phosphorus, and calcium were lower in gastrectomized than in sham rats (p <.05). No significant histological change was observed in the jejunum of Roux-en-Y rats. In the jejunal pouch, we found vascular ingurgitation, inflammation, submucosal, and muscular wall hypertrophy and widening of the villi. In conclusion, total gastrectomy in rats affected the biodistribution of 99mTcO4 to important organs, mainly when a Roux-en-Y reconstruction without a pouch was performed. Moreover, the operation caused biodistribution-related metabolic changes.

ACKNOWLEDGEMENT

This paper was partially funded by a grant from CNPq (470862/07) Brazil.

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