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Journal of Investigative Surgery Volume 7, 1994 - Issue 2
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Original Article

Semi-Quantitative and Qualitative Histologic Analysis Method for the Evaluation of Implant Biocompatibility

J. A. Jansen Department of Oral Function and Prosthetic Dentistry Laboratory of Biomaterials, Dental School University of Nijmegen, 6500, HB, Nijmegen, The Netherlands
,
W. J. A. Dhert University Cluster of Orthopaedics University Hospital Utrecht, 3508, CX, Utrecht, The Netherlands
,
J. P. C. M. Van Der Waerden Department of Oral Function and Prosthetic Dentistry Laboratory of Biomaterials, Dental School University of Nijmegen, 6500, HB, Nijmegen, The Netherlands
&
A. F. Von Recum Department of Bioengineering, Clemson University, Clemson, South Carolina, USA
Pages 123-134 | Received 10 Jun 1992, Accepted 23 Jul 1993, Published online: 09 Jul 2009
 
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Abstract

An adequate histologic evaluation is a prerequisite for a good understanding of the behavior of tissue to implant materials. However, despite improvements in histologic sectioning techniques, few studies have used histomorphometric methods for the quantification of the tissue response. This paper discusses new simple histologic grading scales, which can be used for the fast standardized light microscopic analysis of the biocompatibility of hard and soft tissue implants. Two examples of the application of the grading scales are demonstrated.

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